Rpg Maker Developers Group

After a seven-hour binge of Jimmy & the Pulsating Mass and rebooting my computer, I've found that all RPGMVXA-based games on my computer now refuse to run. Instead, I end up receiving a black screen followed by the game crashing a few seconds later.
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Thus far, I've tried the following with no change in results:

• Restarting my computer
• Uninstalling RPGMaker VX Ace's RTP and reinstalling
• Deleting the Enterbrain registry folder using regedit
• Adding Game.exe to the Data Execution Prevention (attempted for multiple games, no success on any)
• Adding Game.exe to my firewall and antivirus whitelists
  
• Loading an RPGMVXA game from a different hard drive
• Loading an RPGMVXA game based on a different language
• Loading a game using mkxp

Using mkxp-console, I can force the game to start up. The game runs fine, but the save system is completely borked. It won't recognize any save files I have in the directory, won't allow saving files, and hangs for a while attempting to load the save screen. Attempting to enter fullscreen mode has the same effect.
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Has anyone else had this issue? My current system locale is Japanese, but this hadn't changed from before I started playing Jimmy & the Pulsating Mass.